We are a research group at Hubei University of Technology, focusing on Molecular Medicine & Metabolic Engineering (3ME).
On the Molecular Medicine side, we combine physical, chemical, biological, mathematic, bioinformatics and medical techniques to describe molecular structures and mechanisms, identify fundamental molecular and genetic errors of disease, and develop molecular tools or drugs.
On the Metablic Engineering side, we aim to optimize genetic and regulatory processes within cells to increase the production of valuable substances. To this end, we combine different techniques, including gene over-expressing and mutagenesis, pathway modeling and modification, and protein/enzyme engineering.
Our main focus is combining computational and experimental methods to understand the structure, function, and regulation of proteins, in order to develop drugs, molecular tools, and valuable products. We want to provide answers to the following scientific questions:
I. How interactions between proteins gain the dedicated dynamics and biological functions?
II. How protein networks could be tuned?
III. How different protein networks cross-talk and get nicely coupled?
IV. How could a protein network be tailored to benefit our daily life?
The model systems in our group include the KaiABC circadian oscillator and the arginine metabolism network.