Our lab is interested in healthy aging, focusing on understanding the balance between health, aging, and disease states. To that end, we combine computational (dry lab) and experimental (web lab) methods. 

      1. We want to study how protein-protein interaction (PPI) networks (modules) are sustained by protein-protein interaction. Using the polyamine metabolic network as a model, we want to understand how PPI regulates polyamine homeostasis.

      2. We developed the covalent drug discovery protocol SCARdock, the first of its kind for discovering covalent ligands based on non-covalent docking, validated on both nucleophilic and electrophilic targets. We aim to improve the efficiency and expand the application of this protocol. For example, we want to use SCARdock to discover novel covalent ligands targeting undruggable proteins, acting as inhibitors, molecular glues, or PROTACs.

      3. We are interested in the design of protein structure, function, affinity, and orthogonality. On one side, we want to design functional proteins such as industrial enzymes. On the other side, we are interested in understanding how PPI could be targeted for functional protein design.